Scribus Desktop Publishing
Powerful desktop publishing software that helps you create great looking documents of all kinds. It also comes with a lot of support options to help you achieve the best graphic design result. Scribus offers up a freeware desktop publisher that lacks the polish of more popular, pay-for-use programs, but it is free.
Development: Open Source
Type: 2D software
License: Free Noncommercial

3D Bridge for Photoshop
Include 3D imagery and artwork in Photoshop 7, CS, CS2 or CS3. Take your first step into 3D with the free 3D Bridge. Launch DAZ Studio from Photoshop. View 3D scenes as Photoshop layers. Easily pose characters and objects three-dimensionally and see the results immediately in Photoshop.
Development: DAZ Studio
Type: 3D+2D software
License: Free Noncommercial

InsightPoint
This application software creates sophisticated illustration and layout for Web and print. When it comes to spell out and share your ideas, in text and in graphics as well. Besides popular bitmap outputs, InsightPoint can also create high-quality, Web-deployable multipage presentation slide shows.
Development: Icytec Group
Type: 2D software
License: Free Noncommercial

InkScape
Open Source vector graphics editor freeware, with capabilities similar to Adobe Illustrator, Freehand, CorelDraw, or Xara X using the W3C standard Scalable Vector Graphics (SVG) file format. It imports formats such as JPEG, PNG, TIFF, and others and exports PNG as well as multiple vector-based formats.
Development: General Public License (GPL)
Type: 2D software
License: Free Noncommercial

Desktop Graffitist
A small desktop drawing program that enables you to spray paint your desktop, and anything else that might appear on screen. DG is designed for recreation and creativity, and can be used to relieve office stress and boredom. Vandalize your desktop today! Leave messages on other people's computers too...
Development: NGNeer
Type: 2D software
License: Free Noncommercial

ArtRage
Painting and drawing package designed to provide a realistic and fun simulation of using paint on a canvas, along with pens, pencils, crayons, and other tools. ArtRage is available for both Windows and Mac OS X. It can be used with a mouse, but works better if you have a graphics tablet, or even better on a Tablet PC.
Development: Ambient Design Ltd.
Type: 2D software
License: Free Noncommercial

SmoothDraw NX
An easy natural painting and digital free-hand drawing application software that can produce high quality pixel and vector digital art pictures. Support many kinds of brushes (pen, pencil, dry media, airbrush, bristle brush, image hose, etc.), retouch tools, layers, image adjustment, and many illustration effects...
Development: SmoothDraw team
Type: 2D software
License: Free Noncommercial

Pixia
English version of a popular free painting and retouching software that originated in Japan. It features custom brush tips, multiple layers, masking, vector- and bitmap-based drawing tools, color, tone, and lighting adjustments, and multiple undo/redo. Like many freeware editors, no support for GIF format.
Development: Isao Maruoka
Type: 2D software
License: Free Noncommercial